약물 동등용량 비교 (혈압약, 고지혈증약, 위장약)

약국에서 일하다보면 흔히 듣는 질문이 있다.

고지혈증약이 크레스토 5mg에서 리피토 10mg으로 바뀌었는데 약이 더 강해진건가요? 라는 질문이다.

이런 경우 환자는 맨뒤의 숫자만 보고 생각하는 것이다.

리피토 10mg이 크레스토 5mg보다 숫자가 2배 크니까 2배 강하다고 생각하는 것

같은 계열의 약이라도 성분이 다르면 뒤의 숫자만으로 비교하면 안된다.

고지혈증약 성분별 효과가 같은 용량은 다음과 같다.

Atorvastatin (Lipitor ®): -- (see tablet strengths)	Fluvastatin (Lescol ®): 20 mg	Lovastatin (Mevacor ®): 10 mg
Pravastatin (Pravachol ®): 10 mg	Rosuvastatin (Crestor ®): --	Simvastatin (Zocor ®): 5 mg

Atorvastatin (Lipitor ®): --	Fluvastatin (Lescol ®): 40 mg	Lovastatin (Mevacor ®): 20 mg
Pravastatin (Pravachol ®): 20 mg	Rosuvastatin (Crestor ®): --	Simvastatin (Zocor ®): 10 mg

Atorvastatin (Lipitor ®): 10 mg	Fluvastatin (Lescol ®): 80 mg	Lovastatin (Mevacor ®): 40 mg
Pravastatin (Pravachol ®): 40 mg	Rosuvastatin (Crestor ®): 5 mg	Simvastatin (Zocor ®): 20 mg

Atorvastatin (Lipitor ®): 20 mg	Fluvastatin (Lescol ®): --	Lovastatin (Mevacor ®): 80 mg
Pravastatin (Pravachol ®): 80 mg	Rosuvastatin (Crestor ®): 5 - 10 mg	Simvastatin (Zocor ®): 40 mg

Atorvastatin (Lipitor ®): 40 mg	Fluvastatin (Lescol ®): --	Lovastatin (Mevacor ®): --
Pravastatin (Pravachol ®): --	Rosuvastatin (Crestor ®): 10 - 20 mg	Simvastatin (Zocor ®): 80 mg

가장 마지막 표를 기준으로 하면

Atorvastatin 40mg = Rosuvastatin 10~20mg = Simvastatin 80mg이다.

Esomeprazole (Nexium ®): 20 - 40 mg	Lansoprazole (Prevacid ®): 30 mg	Omeprazole (Prilosec ®): 20 mg
Pantoprazole (Protonix ®): 40 mg	Rabeprazole (Aciphex ®): 20 mg	--

Candesartan (Atacand ®):
8 mg

Eprosartan (Tevetan ®):
400 mg

Irbesartan (Avapro ®):
75 mg

Losartan (Cozaar ®):
25 mg

Olmesartan (Benicar ®):
10 mg

Telmisartan (Micardis ®):
20 mg

Valsartan (Diovan ®):

40 mg

Candesartan (Atacand ®):
16 mg

Eprosartan (Tevetan ®):
600 mg

Irbesartan (Avapro ®):
150 mg

Losartan (Cozaar ®):
50 mg

Olmesartan (Benicar ®):
20 mg

Telmisartan (Micardis ®):
40 mg

Valsartan (Diovan ®):

80 mg

이 표는 얼마전 발사르탄 발암물질 사태로 상당히 유용하게 써먹었다.

발사르탄 카피약들이 대부분 오리지널 약으로 바뀌었지만 같은 계열의 다른약으로 바꾸는 경우도 있었기 때문

ENALAPRIL 2.5 MG IS EQUIVALENT TO:
benazepril 5 mg	captopril 25 mg	fosinopril 5 mg
lisinopril 5 mg	moexipril 3.75 mg	Perindopril 2 mg
quinapril 5 mg	ramipril 1.25 mg	Trandolapril 1 mg

ENALAPRIL 5 MG IS EQUIVALENT TO:
benazepril 10 mg	captopril 50 mg	fosinopril 10 mg
lisinopril 10 mg	moexipril 7.5 mg	Perindopril 4 mg
quinapril 10 mg	ramipril 2.5 mg	Trandolapril 2 mg

Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Major Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Major Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Major Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Major Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Major Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Major Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Major Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Major Elimination Route:
Drug: Beta-1 Selective: ISA:
Approximate Dose Equivalence: Major Elimination Route: